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Entries:
Primary culture of mast cells and mast cell lines in rodent and humans
I. Introduction Mast cell (MC) progenitors, derived from hematopoietic progenitors (HP), circulate in the bloodstream and reach tissues to undergo terminal maturation upon the influence
Role of tetraspanins in mast cells
Tetraspanins are modulators of mast cell degranulation Mast cell (MC) degranulation basically is the result of FceRI cross-linking by IgE bound antigen. However, this process
STIM1 in mast cell signaling
STIM1 signaling pathway The stromal interaction molecule 1 (STIM1) is a protein embedded predominantly in endoplasmic reticulum (ER) membrane via its transmembrane domain. It is
The role of mast cells in cutaneous leishmaniasis
Leishmania is an important cutaneous pathogen and more than 12 million people worldwide are currently infected. Almost 60,000 individuals die of complications associated with leishmaniasis
The role of mast cells in the microenvironment of tumors
Hallmarks of cancer The hallmarks of cancer include, according to Hanahan and Weinberg1, ten different mechanisms, as shown in Figure 1. Inflammation plays an important
Transmembrane adaptor proteins in mast cells
Transmembrane adaptor proteins (TRAPs) facilitate activation within signal transduction pathways but lack both intrinsic enzymatic and transcriptional activities. They are characterized by a short extracellular
