The Israel Academy of Sciences and Humanities established a prestigious program in 2018 to bring outstanding post-docs from around the world to Israel’s research universities. The Israel Young Academy led by Prof. Yonina Eldar, suggested this as a solution to the need to strengthen research in Israel. The program’s purpose is to attract young outstanding scholars from around the world to come to Israel and integrate into and strengthen research and make personal and professional contacts with Israeli researchers, ultimately leading to future research collaboration. The awarding committee, headed by Academy Member Prof. Moti Segev, was appointed to accomplish this objective. The committee is comprised of Academy Members and faculty from a wide range of disciplines of the sciences and humanities from a variety of Israeli universities, and includes a prominent scientist from abroad. The awardees are chosen solely based on their excellence in research. This year the program was
Postdoctoral Associates: The role of Mast cells in the Vascular Pathology of Shock and Ischemia/Reperfusion Injury.
Two postdoctoral positions are available jointly in the Department of Anesthesiology and Department of Pathology at Duke University Medical Center. Projects are funded for up to 4 years by recently approved grants from the NIH and the American Heart Association and will examine the role of mast cells at the vascular/tissue interface. Specifically, they will determine: Vascular pathology during the transition of sepsis to septic shock. This project aims to determine the triggering events for development of shock in sepsis using various mouse models and assays of vascular permeability, microvascular perfusion (photoacoustic imaging) and shock (pressure sensing telemetry implants). Karhausen J et al. Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury. Sci. Adv. 2020 doi: 10.1126/sciadv.aay6314. Choi HW et al. Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles. Science. 2018 doi: 10.1126/science.aao0666. Vascular permeability, neutrophil recruitment and neuronal
Post-doctoral position at the Seattle Children’s Research Institute, Department of Pediatrics, University of Washington (Seattle, WA)
DESCRIPTIONA post-doctoral position is available within the laboratory of Dr. Adrian Piliponsky at Seattle Children’s Research Institute, Department of Pediatrics, Pathology and Global Health, University of Washington (Seattle, WA). Research in Dr. Piliponsky’s lab is focused on the regulation of inflammatory processes involving mast cells and myeloid cells, including allergy inflammation and inflammation during bacterial infections. Publications of interest can be found at: Piliponsky AM et al. Immunol Rev 2018 (PMID 29431211), Piliponsky AM et al. Nat Immunol 2019 (PMID 30664762), Shubin NJ et al. Mucosal Immunol 2020 (PMID 32103153), Saha SS et al. J Allergy Clin Immunol 2021 (PMID 34324892). The post-doctoral hired for the position will use an array of cellular and molecular approaches (ELISA, cell isolation, flow cytometry, histology, RNAseq and transcriptome analysis, qPCR, bacterial propagation; as well as animal models of bacterial infection and allergic airway and skin inflammation using mast cell and basophil specific conditional