European Mast Cell and
Basophil Research Network


List of publications by EMBRN members

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You can get access to this area and its contents if you are a member of EMBRN. A membership with EMBRN provides you with access to EMBRN experimental protocols, recent papers from the EMBRN lab and an updated member list.

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Mast cell silencing: a novel therapeutic approach for urticarial and other mast cell-mediated diseases

Summary Chronic urticaria (CU) is a mast cell (MC)-dependent disease with limited therapeutic options. Current management strategies are directed at inhibiting IgE-mediated activation of MCs and antagonizing effects of released mediators. Due to the complexity and heterogeneity of CU and other MC diseases and mechanisms of MC activation—including multiple activating

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Directional mast cell degranulation of tumornecrosis factor into blood vessels primes neutrophilextravasation

Summary Tissue resident mast cells (MCs) rapidly initiate neutrophil infiltration upon inflammatory insult, yet the molecular mechanism is still unknown. Here, we demonstrated that MC-derived tumor necrosis factor (TNF) was crucial for neutrophil extravasation to sites of contact hypersensitivity-induced skin inflammation by promoting intraluminal crawling. MC-derived TNF directly primed circulating

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