Summary Fevipiprant, a DP2 receptor antagonist, inhibits eosinophil migration towards mast cells Citation Fevipiprant, a DP2 receptor antagonist, inhibits eosinophil migration towards mast cells. Shamri R, Dubois G, Erpenbeck VJ, Mankuta D, Sandham DA, Levi-Schaffer F. Clin Exp Allergy. 2019 Feb;49(2):255-257. doi: 10.1111/cea.13304. Epub 2018
Summary Mast cells (MC) accumulate in colorectal cancer (CRC) and the relationship between MC density and cancer progression has been well recognized. Citation Yu Y, Blokhuis BRJ, Diks MAP, Keshavarzian A, Garssen J and Redegeld FA (2018) Functional Inhibitory Siglec-6 Is Upregulated in Human Colorectal
Summary Mast cells have been identified as resident cells of human placental tissue by immunohistological procedures, suggesting that they may play a role in pregnancy. Citation Mezouar, Soraya & Ben Amara, Amira & Vitte, Joana & Mege, Jean‐Louis. (2018). Isolation of Human Placental Mast Cells.
Summary Chronic inflammation drives the development of colorectal cancer (CRC), where tumor-infiltrating immune cells interact with cancer cells in a dynamic crosstalk. Citation Yingxin Yu, Bart Blokhuis, Yvonne Derks, Sangeeta Kumari, Johan Garssen & Frank Redegeld (2018) Human mast cells promote colon cancer growth via