Mast cells are emerging players in physiological and pathological pain pathways. Mast cells are frequently found in close proximity to nociceptive neurons and therefore can participate in juxtacrine signaling in neuro-immune synapses (1).  Mast cells induce nociceptor activation through the release of chemical mediators during

Tetraspanins are modulators of mast cell degranulation Mast cell (MC) degranulation basically is the result of FceRI cross-linking by IgE bound antigen. However, this process is mediated by a complex signaling machinery, sometimes referred to as the FceRI signalosome (1). Tetraspanin proteins have been named