Fevipiprant, a DP2 receptor antagonist, inhibits eosinophil migration towards mast cells
Fevipiprant, a DP2 receptor antagonist, inhibits eosinophil migration towards mast cells. Shamri R, Dubois G, Erpenbeck VJ, Mankuta D, Sandham DA, Levi-Schaffer F. Clin Exp Allergy. 2019 Feb;49(2):255-257. doi: 10.1111/cea.13304. Epub 2018 Nov 25. PMID: 30379368
Summary Chronic urticaria (CU) is a mast cell (MC)-dependent disease with limited therapeutic options. Current management strategies are directed at inhibiting IgE-mediated activation of MCs and
Summary Staphylococcus aureus (SA) and its exotoxins activate eosinophils (Eos) and mast cells (MCs) via CD48, a GPI-anchored receptor belonging to the Signaling Lymphocytes Activation Molecules (SLAM)
K. Frank Austen, a remarkable, dedicated mast cell scientist and mentor over almost seven decades, passed away on June 23rd at an age of 95 years.