Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness, airway inflammation, and airway remodeling. Mast cells (MC) activated through IgE, and specific allergens, release mediators that drive early phase reactions (EPR), contribute to late phase reaction (LPR), and also take part in airway remodeling.

Mast cells (MCs) are sentinel cells of the immune system and are found in greater numbers at sites of pathogen exposure such as the skin andairways. MCs are bestowed with different types of Toll like receptors (TLRs) that are important in the recognition of pathogens