Summary Tissue resident mast cells (MCs) rapidly initiate neutrophil infiltration upon inflammatory insult, yet the molecular mechanism is still unknown. Here, we demonstrated that MC-derived tumor necrosis factor (TNF) was crucial for neutrophil extravasation to sites of contact hypersensitivity-induced skin inflammation by promoting intraluminal crawling.
The International Eosinophil Society 2nd Virtual Seminar, February 24th. IES February Virtual Seminar: Eosinophils and CancerFebruary 24th9:30am-10:45am ET Invited Speakers:Prof. Ariel Munitz, Tel Aviv UniversityProf. Viktor Umansky, Heidelberg UniversityProf. Gabrielle Belz, Walter and Eliza Hall Institute https://www.eosinophil-society.org/educational-opportunities/virtual-seminar-forum
Summary B lymphocytes are among the cell types whose effector functions are modulated by mast cells (MCs). The B/MC crosstalk emerged in several pathological settings, notably the colon of inflammatory bowel disease (IBD) patients is a privileged site in which MCs and IgA+ cells physically
Our sister society, the International Eosinophil Society (IES) has initiated a series of monthly webinars addressing a large public of scientists and clinicians. The first IES webinar, held on January 27th (9:30 am EST, 3:30 pm CET) will be dedicated to eosinophils and COVID-19. http://www.eosinophil-society.org/educational-opportunities/virtual-seminar-forum
we would like to host a series of 90-minute webinars, every 2-3 months, with a keynote speaker and presentations from MSc, PhD students and postdoctoral researchers, who will be completing their studies, or other graduate students with very interesting results. The theme of the first
Summary Unsupervised mapping of leukocyte surface markers identified a granulocytic COVID-19 signature comprising eosinophil and basophil CRTH2 downregulation, increased counts of CD15+CD16+ neutrophils, and decreased granulocytic CD11b expression, while PDL1 checkpoint expression in basophils and eosinophils was associated with severity. Citation A granulocytic signature identifies
Deadline for manuscript submissions: 31 March 2021International Journal of Molecular Sciences (impact factor 2019/2020: 4.556)Guest Editor: Prof. Dr. Margarita Martín Goto Calls for Projects
Summary Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, pidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection from tumour growth. Intriguingly, recent studies reveal a correlation between IgE deficiency and increased malignancy
Summary In this review, we identify opportunities for drug discovery in the treatment of COVID-19 and in so doing, provide a rational roadmap whereby pharmacology and pharmacologists can mitigate against the global pandemic. We assess the scope for targetting key host and viral targets in
July 17-22, 2022 Glasgow, Scotland, UK