Summary
Unsupervised mapping of leukocyte surface markers identified a granulocytic COVID-19 signature comprising eosinophil and basophil CRTH2 downregulation, increased counts of CD15+CD16+ neutrophils, and decreased granulocytic CD11b expression, while PDL1 checkpoint expression in basophils and eosinophils was associated with severity.
Citation
A granulocytic signature identifies COVID-19 and its severity. Vitte J, Diallo AB, Boumaza A, Lopez A, Michel M, Allardet-Servent J, Mezouar S, Sereme Y, Busnel JM, Miloud T, Malergue F, Morange PE, Halfon P, Olive D, Leone M, Mege JL. J Infect Dis. 2020 Sep 17:jiaa591. doi: 10.1093/infdis/jiaa591. Online ahead of print. PMID: 32941618