European Mast Cell and
Basophil Research Network

A granulocytic signature identifies COVID-19 and its severity

September 17, 2020

Summary

Unsupervised mapping of leukocyte surface markers identified a granulocytic COVID-19 signature comprising eosinophil and basophil CRTH2 downregulation, increased counts of CD15+CD16+ neutrophils, and decreased granulocytic CD11b expression, while PDL1 checkpoint expression in basophils and eosinophils was associated with severity.

Citation

A granulocytic signature identifies COVID-19 and its severity. Vitte J, Diallo AB, Boumaza A, Lopez A, Michel M, Allardet-Servent J, Mezouar S, Sereme Y, Busnel JM, Miloud T, Malergue F, Morange PE, Halfon P, Olive D, Leone M, Mege JL. J Infect Dis. 2020 Sep 17:jiaa591. doi: 10.1093/infdis/jiaa591. Online ahead of print. PMID: 32941618

Download

Looking for other posts?

EMBRN Council elections

Our society needs to renew part of its Council for the next mandate During the general assembly of our society that will take place during the

March 25, 2024

Federation of Clinical Immunology Societies (FOCIS)-European Academy of Allergy and Clinical Immunology (EAACI) in partnership with the European Mast Cell and Basophil Research Network (EMBRN) joint symposium

Agenda June 18th, 2024 10:00-11:30 am EAACI symposium title: Immune responses at the barrier sites through the lenses of new nomenclature of allergy and clinical immunology Symposium Objective:

March 24, 2024

Autoreactive IgE: Pathogenic role and therapeutic target in autoimmune diseases

Summary Autoimmunity is the break of tolerance to self-antigens that leads to organ-specific or systemic diseases often characterized by the presence of pathogenic autoreactive antibodies (AAb)

February 2, 2024