European Mast Cell and
Basophil Research Network

Author: Marc Freichel

TRP proteins: regulators of Ca2+ entry and mast cell activation

Ca2+ entry pathways for mast cell activation In mast cells, the increase of free cytosolic Ca2+ regulates a variety of cellular processes including degranulation with release of preformed inflammatory mediators, production of eicosanoids, activation of transcription factors including the nuclear factor of activated T cells

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