List of publications by EMBRN members
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Mast Cell Cytonemes as a Defense Mechanism against Coxiella burnetii
Summary Mast cells (MCs) are critical mediators of inflammation; however, their microbicidal activity against invading pathogens remains largely unknown. Here, we describe a nonpreviously reported antibacterial mechanism used by MCs against Coxiella burnetii, the agent of Q fever. We show that C. burnetii interaction with MCs does not result in
Progenitor mast cells and tryptase in Q fever
Summary Q fever is an infectious disease due to Coxiella burnetii. Following a primary-infection, C. burnetii may persist in some patients, leading to endocarditis and vascular infections. Mast cells (MCs), known for their role in allergic diseases, innate immunity and cardiac function, are produced by bone marrow, circulate as progenitors
Fevipiprant, a DP2 receptor antagonist, inhibits eosinophil migration towards mast cells
Summary Fevipiprant, a DP2 receptor antagonist, inhibits eosinophil migration towards mast cells Citation Fevipiprant, a DP2 receptor antagonist, inhibits eosinophil migration towards mast cells. Shamri R, Dubois G, Erpenbeck VJ, Mankuta D, Sandham DA, Levi-Schaffer F. Clin Exp Allergy. 2019 Feb;49(2):255-257. doi: 10.1111/cea.13304. Epub 2018 Nov 25. PMID: 30379368 Download
Functional Inhibitory Siglec-6 Is Upregulated in Human Colorectal Cancer-Associated Mast Cells
Summary Mast cells (MC) accumulate in colorectal cancer (CRC) and the relationship between MC density and cancer progression has been well recognized. Citation Yu Y, Blokhuis BRJ, Diks MAP, Keshavarzian A, Garssen J and Redegeld FA (2018) Functional Inhibitory Siglec-6 Is Upregulated in Human Colorectal Cancer-Associated Mast Cells. Front. Immunol.
