Postdoctoral Associates: The role of Mast cells in the Vascular Pathology of Shock and Ischemia/Reperfusion Injury.
Two postdoctoral positions are available jointly in the Department of Anesthesiology and Department of Pathology at Duke University Medical Center. Projects are funded for up to 4 years by recently approved grants from the NIH and the American Heart Association and will examine the role of mast cells at the vascular/tissue interface. Specifically, they will determine: Vascular pathology during the transition of sepsis to septic shock. This project aims to determine the triggering events for development of shock in sepsis using various mouse models and assays of vascular permeability, microvascular perfusion (photoacoustic imaging) and shock (pressure sensing telemetry implants). Karhausen J et al. Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury. Sci. Adv. 2020 doi: 10.1126/sciadv.aay6314. Choi HW et al. Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles. Science. 2018 doi: 10.1126/science.aao0666. Vascular permeability, neutrophil recruitment and neuronal
Post-doctoral position at the Seattle Children’s Research Institute, Department of Pediatrics, University of Washington (Seattle, WA)
DESCRIPTIONA post-doctoral position is available within the laboratory of Dr. Adrian Piliponsky at Seattle Children’s Research Institute, Department of Pediatrics, Pathology and Global Health, University of Washington (Seattle, WA). Research in Dr. Piliponsky’s lab is focused on the regulation of inflammatory processes involving mast cells and myeloid cells, including allergy inflammation and inflammation during bacterial infections. Publications of interest can be found at: Piliponsky AM et al. Immunol Rev 2018 (PMID 29431211), Piliponsky AM et al. Nat Immunol 2019 (PMID 30664762), Shubin NJ et al. Mucosal Immunol 2020 (PMID 32103153), Saha SS et al. J Allergy Clin Immunol 2021 (PMID 34324892). The post-doctoral hired for the position will use an array of cellular and molecular approaches (ELISA, cell isolation, flow cytometry, histology, RNAseq and transcriptome analysis, qPCR, bacterial propagation; as well as animal models of bacterial infection and allergic airway and skin inflammation using mast cell and basophil specific conditional
We are searching for motivated and outstanding MSc/PhD/MD/PostDoc research students to take on challenging projects in the field of Allergy, Cancer, Corona virus and Antibody-mediated therapy
Lab work includes immunological, molecular biology and microbiology methods, as well as in vivo mouse models of disease and work on human cells. Projects: Mechanisms underlying the pathophysiology of skin and airway allergic disease (Atopic dermatitis and asthma) Resolution processes of allergic inflammation Activating and inhibitory receptors on mast cells and eosinophils The role of inhibitory receptors on solid tumors (from melanoma to colon cancer) The interaction of mast cells and eosinophils with bacteria and fungi Corona virus: are mast cells and eosinophils involved in host protective or offensive mechanisms? For more information please contact: Professor Francesca Levi-Schaffer: francescal@ekmd.huji.ac.ilHead of Immunopharmacology lab, Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
