European Mast Cell and
Basophil Research Network

Author: Monika Bambousková

Actin cytoskeleton in FcεRI signaling events in mast cells

Actin cytoskeleton has been implicated at early FcεRI-mediated signaling events as well as at later steps leading to degranulation and/or cell migration (1). In initial biochemical studies aggregation of the FcεRI caused rapid decrease in the amount of filamentous (F)-actin followed by its subsequent increase

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Transmembrane adaptor proteins in mast cells

Transmembrane adaptor proteins (TRAPs) facilitate activation within signal transduction pathways but lack both intrinsic enzymatic and transcriptional activities. They are characterized by a short extracellular domain, a single transmembrane domain and a cytoplasmic tail with various motifs serving as anchors for cytoplasmic signaling molecules. TRAPs

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STIM1 in mast cell signaling

STIM1 signaling pathway The stromal interaction molecule 1 (STIM1) is a protein embedded predominantly in endoplasmic reticulum (ER) membrane via its transmembrane domain. It is a key regulator of calcium release activated calcium (CRAC) channel responsible for store operated calcium entry (SOCE) formerly known as

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